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Drug resistance in D. discoideum: isolation of 4-nitroquinoline 1-oxide resistant mutants
(University of Missouri--Columbia, 2005)
response to 4NQO in Dictyostelium discoideum. To study the molecular basis of 4NQO resistance in Dictyostelium, I used restriction enzyme mediated integration (REMI), a direct insertional mutagenesis approach, to isolate 4NQO resistant mutants. This study...
Sphingolipid metabolic enzymes modulate anticancer drug resistance
(University of Missouri--Columbia, 2006)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] One of the most challenging aspects of cancer therapy today is the problem of drug resistance. The aim of our research is to understand the molecular basis of anticancer drug...
Regulation of ceramide synthase 1 in cellular stress response
(University of Missouri--Columbia, 2008)
[ACCESS RESTRICTED TO THE UNIVERSITY OF MISSOURI AT REQUEST OF AUTHOR.] Ceramides are intimately involved in a wide range of cellular processes. In mammals, de novo ceramide synthesis is catalyzed by the 6 ceramide synthase enzymes, which...